The role of von Willebrand factor in hemostasis pathology

Von Willebrand factor (VWF) is a multimeric plasma glycoprotein present in endothelial cells, megakaryocytes, platelets, and connective tissue. It mediates platelet adhesion small arteries. VWF also binds protects coagulation VIII from degradation. Moreover, involved inflammatory response, linking hemostasis inflammation. multimers platelets attached to damaged or activated endothelium mediate leukocyte recruitment, facilitating local response. At shear rates above 5000 s –1 , molecules are capable of hydrodynamic activation that changes their conformation globular fibrillar. Therefore, plays key role cellular at high rates. Acquired inherited disfunction, defective synthesis increased proteolysis lead bleeding, as von disease Heyde syndrome. Pathological may the development thrombotic complications coronary artery disease. COVID-19, especially severe form, characterized by prothrombotic shift pulmonary vascular bed. Following damage, level rises ADAMTS-13 activity decreases. In patients with change VWF/ADAMTS-13 ratio associated an increase risk thromboembolic complications. assessment under flow conditions be valuable fundamental research laboratory diagnostics.